Renin Test

Renin Test or Renin assay is a diagnostic process to find the exact causative factor of hypertension to module a correct treatment plan. It is also known as plasma remain activity (PRA) or aldosterone. Plasma Renin ration(ARF), mainly helps to find out what is happening within the body.

Renin is an enzyme produced by specialized cells within the kidney that chiefly works by controlling blood pressure. Renin is also called Angiotensinogen. Plasma Renin helps to control your blood pressure and causes an increase in blood pressure when blood pressure is low.

Other Names Of Renin Test:

The renin Test also called the Renin Assay test, is also called the plasma Renin Activity Test. Also called the plasma Renin Angiotensin Test.

Function:

When your blood pressure is too low or your body is deficient in salt, kidneys release renin in the bloodstream. Renin converts Angiotensinogen (protein) produced by the liver into Angiotensin1 (Hormone). Angiotensin 1 Hormone is converted into Angiotensin II hormone in the lungs by angiotensin-converting enzyme (ACE)- Angiotensin II signals your adrenal glands to release aldosterone (Hormone). Angiotensin narrows the small blood vessels, and aldosterone tells your kidneys to retain salts and fluid. Both of these conditions will raise your blood pressure.

Symptoms Of High Renin Test:

You may need a renin test if you have been diagnosed with high blood pressure. These symptoms included:

• Cramps
• Weakness
• Excessive thirst
• Fatigue
• Headache

Symptoms Of Low Renin:

When the weakness and low potassium levels in your bad (Hypokalemia). These can include:

• Heart Disease
• Stroke
• Heart attack
• Atrial fibrillation

Causes Of High Renin in Blood:

• Adrenal gland tumor
• Addison’s Disease
• Renovascular Hypertension
• Low Sodium Diet
• Cirrhosis and Heart failure
• Secondary Hyperaldosteronism
• Chronic Renal Failure
• Malignant Hypertension
• Barter’s Syndrome
• Nephropathy and Transplant Rejection
• Pregnancy and menses
• Hypokalemia

Causes of Low Renin in Blood:

• Conn Disease
• Volume Overload
• primary aldosterone’s
• Treatment with steroids
• Liddle’s syndrome
• Congenital Syndrome
• Essential Hypertension
• High Sodium diet
• Weight Loss

Normal Range Of Renin Test:

Patient on a Normal Sodium diet
Adult Supine: 0.2-1.6ng/ml/hour or Adult Standing: 0.7-33ng/ml/hour

Purpose:

• To evaluate the treatment of hypertension
• To Diagnose primary hyper Aldosteronism
• Assist in the screening of essential hypertension or due to renal orrenovasenlar hypertension

Procedure:

• The patient should be on a normal Sodium diet ( 1 to 2 g sodium per day) for 2 weeks before the test.
• The patient should avoid and block ACE inhibitors, aspirin, cortical steroids, and estrogen 2 to 4 weeks before the test.
• The phlebotomist asks the patient to do it or be down to relax for 1 to 2 hours before the blood is collected.
• Draw the blood sample from the vein in the arm. Collect 3 to 5ml blood after & hours of fasting in EDTA Tube.
• The patient’s posture at the time of collection should be noted.
• Centrifuge the blood sample and separate the plasma or serum.
• Plasma or serum is used for the test and analysis of the value of the Renin test.

Result Interpretation:

In most cases, the doctor usually compares the renin test with the aldosterone test results. The results may Show one of the following.

• Lower than normal Renin, / Flower than normal aldosterone: Eradicate you may have Cushing’s Syndrome.
• Lower than normal Renin, / Higher than normal aldosterone: Primary aldosteronism.
• Higher them normal Renin, / Lower than normal aldosterone: Indicates you may have Addison
  disease.
• Higher than normal Renin, / Higher than normal aldosterone: This means you have Secondary aldosteronism.