Creatinine Clearance Test
Creatinine Clearance Test, Blood amount kidneys are making creatinine-free each minute. Creatinine is never reabsorbed only a minute secreted.
Cr Filtrate: Cr Excreted:
Rate of filtration:
Rate of filtration GFR: Glomerular filtration rate.
Amount of fluid that filters into the Bowman’s Capsule per unit of time. 125 ml/mnt.
The total value of GFR: Sum of filtration rates of all of the functioning nephrons 180 L/day.
Renal Clearance:
Renal Clearance: The volume of plasma that is completely cleaned of substances by the kidney per unit of time.
Zero clearance:
Reabsorbed 100%. eg Glucose.
Complete clearance:
O% reabsorbed, not secreted from blood to nephrons eg Inulin.
Partial clearance:
90% filtrated into Bowman’s very little secreted minute amounts reabsorb eg Creatine.
Calculation oF GFR:
Direct: Creatinine clearance [Urine Test] 24 hours:
- Creatinine clearance GFR:
- Creatinine clearance:
- [Urinary ] Cr x volume of Per min, [Plasma] Cr, Cr EL 90-140 mL/min.
Indirect Serum Creatinine:
- Blood Test: Estimated GE/e-GFR.
Factor Affecting:
- Body Mass
- Gender
- Age (Important factor)
GFR: 1mL/min/year
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