CA 15-3 Test, Cancer antigen 15-3 is a glycoprotein that has been found in benign malignant disease of the breast, as well as breast carcinoma that has metastasized to the liver or bone. It is highest CA-15-3 values are found in metastatic breast disease Testing for CA 15-3 is useful in the diagnosis of metastatic breast cancer and for the monitoring of patient response to breast cancer treatment.
CA 15-3 value does not increase in early malignancy of the breast, it is not useful as a Screening test. Elevated CA 15-3 levels have also been found in patients without cancer and patients. with other cancer. such as liver, lung, and ovarian Cancer the level of CA15-3 is the more advanced the breast cancer and the greater the likelihood of metastasis.
Function OF CA 15-3:
CA 15-3 is a substance that stimulates your body’s defense system. Some kinds of cancer cells release the CA 15-3 antigen into the blood. CA 15-3 test is used for certain types of cancer. Breast cancer is cancer most likely to release CA 15-3, especially in breast cancer that comes back after treatment.
Risk Factors of Breast Cancer:
- Getting older
- Genetic mutations
- Reproductive History
- Having dense breasts
- Family history of breast or ovarian cancer
- Previous treatment using radiation therapy
Symptoms OF CA 15-3 (Breast cancer):
- New lump in the breast or underarm (armpit)
- Thickening or swelling of part of the breast
- Irritation or dimpling of breast skin
- Redness or flashy skin in the nipple area or the breast
- Pain in the nipple area pulling in the ripple
- Nipple discharge other than breast milk, including blood
- Change the size and shape of the breast
- Pain in any area of the breast
Normal Range Of CA 15-3:
CA 15-3 Less Than 30 U/ml
Causes Of High CA 15-3 Level:
- Cirrhosis
- Colon rectal Cancer (known as bowel, colon, or rectum cancer)
- Fibrocystic breast disease
- Liver Cancer
- Lung Cancer
- Metastatic Cancer
- Sarcoidosis
- Systemic Lupus Erythematosus
How to perform the Test?
Procedure:
Take 3 to 5 ml of blood sample in a red top tube or gel tube. Centrifuge the blood sample and separate the serum. Take serum and run on Elisa or other special chemistry analyses like Architech.
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